Hericium erinaceus
Lion's Mane
CognitionNGF synthesisNeuroplasticityAnxiety
Category
Cognitive
Dose range
500–3000 mg
Beta-glucan
25–40%
Timing
Morning + midday with food
Key compound
Hericenones & Erinacines
Overview
Lion's mane is the only functional mushroom known to stimulate nerve growth factor (NGF) synthesis. The bioactive compounds hericenones (from the fruiting body) and erinacines (from mycelium) cross the blood-brain barrier and promote neurogenesis. Clinical trials show measurable improvement in mild cognitive impairment at doses of 500–3,000 mg daily.
Primary reference
Mori K, Inatomi S, Ouchi K, et al. · 2009
Improving effects of the mushroom Yamabushitake on mild cognitive impairment: a double-blind placebo-controlled clinical trial
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Adjusted for bodyweight and extract form